What is Estramustine 140mg?
Estramustine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Estramustine 140mg is used to treat metastatic or progressive prostate cancer. Estramustine may also be used for purposes not listed in this medication guide.
estramustine uses to treat some types of prostate cancer. In the body, estramustine breaks down into estrogens (estrone, estradiol) and a type of cancer drug (estromustine). This medication is thought to work by increasing estrogens, which interfere with prostate cancer, and by slowing/stopping the growth of cancer cells.
How to use
Take this medication by mouth on an empty stomach, either 1 hour before or 2 hours after a meal, usually 3-4 times a day or as directed by your doctor.Take this medication with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise.Take this medication regularly in order to get the most benefit from it.
Remember to take it at the same times each day as directed. The dosage is based on your medical condition, weight, and response to therapy.
Take this medication 3 hours before or after taking any products containing magnesium, aluminum, or calcium. Some examples include quinapril, didanosine, vitamins/minerals, and antacids. Dairy products (e.g., milk, yogurt), calcium-enriched juice, sucralfate, bismuth subsalicylate, iron, and zinc are also included. These products bind with estramustine, preventing its full absorption.Do not increase your dose or take this medication more often than prescribed.
Mechanism of Action.
Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells
These all are Estramustine side effects including here
- breast tenderness or enlargement
- decreased interest in sex
- decreased sexual ability
- muscle weakness
- stomach upset
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
You should not take Emcyt if you are allergic to Estramustine or if you have any other allergies.
Before you start taking estramustine , talk to your doctor about your medical history and about all the medications he takes including OTC and herbal medications.
You should not smoke cigarettes or use tobacco. Estrogens combined with smoking further increases your risk for stroke, blood clots, high blood pressure and heart attacks. Emcyt may cause a patchy darkening of facial skin (melisma).
This medication may affect the production of sperm. There may be an interaction between Estramustine and other medications such as ACE inhibitors, anabolic steroids, androgens, calcium and products containing calcium, estrogens and tricyclic antidepressants, etc.
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