What is Temoside 100mg?
Temoside 100mg Capsule is an anticancer agent used in the treatment of certain types of brain cancers. Temoside 100mg should be used with caution in patients with a known history of hepatic and renal impairment. It is not recommended for use in children under 3 years of age.
Uses of Temoside 100mg Capsule
temozolomide uses in the treatment of Anaplastic Astrocytoma (a type of brain cancer).
Temoside 100 mg Capsule is used in the treatment of glioblastoma multiforme (a type of brain cancer).
How Temoside Capsule works
Temoside 100 mg Capsule is an anti-cancer medication. It enters the brain tissues and works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
How to use Temoside Capsule
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole.Do not chew, crush or break it. Temoside 100 mg Capsule is to be taken empty stomach.
Mechanism of Action of Temoside 100mg :
Temozolomide, A Triazene, Is An Inactive Prodrug. It Is Chemically Hydrolysed To 3-Methyl-(Triazen-1-Yl) Imidazole-4-Carboxamide (MTIC), The Active Metabolite Of Dacarbazine. The Cytotoxicity Of MTIC Is Believed To Be Due Alkylation Of DNA, Mainly At The O6 And N7 Positions Of Guanine. Absorption: Rapidly And Completely Absorbed From GI Tract. Peak Plasma Concentration: 0.5-1.5 Hr. Rate And Extent Of Absorption Decreased By Food. Distribution: Protein Binding: 15%. Cross Blood-Brain Barrier. Metabolism: Undergoes Rapid Nonenzymatic Conversion At Physiologic PH To The Reactive Compound MTIC And To Temozolomide Acid Metabolite. MTIC Is Further Hydrolysed To 5-Amino-Imidazole-4-Carboxamide (AIC) And Methylhydrazine. Excretion: Excreted Mainly In Urine As Unchanged Drug, AIC, Temozolomide Acid Metabolite And Unidentified Polar Metabolites. Plasma Half Life: 1.8 Hr.
Major & minor temozolomide side effects are here:-
- Nausea and Vomiting
- Loss of appetite
- Hair loss
- Mental depression
- Runny Nose
If you miss a dose of Temoside 100 mg Capsule or a scheduled appointment for a dose of Temoside 100 mg Capsule, call your doctor immediately for further instructions. Do not use extra medicine to make up for a missed dose.
Oral: Seek emergency medical treatment or contact the doctor immediately in case of a suspected overdose. Injection: Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose with this medicine is suspected.
Special Precautions for Temoside 100mg Cap 5s:
Severe Hepatic And Renal Impairment. Elderly >70 Yr, Children. Women Of Child Bearing Potential Should Avoid Becoming Pregnant During Therapy.
Males Should Be Advised Not To Father A Child Up To 6 Mth After Treatment And To Consider Cryoconservation Of Sperms Due To Possibility Of Irreversible Infertility. Unknown If Distributed Into Breastmilk, Discontinue Nursing Due To Potential Risk.
temoside 100mg May Impair Ability To Drive Or Operate Machinery. Swallow Capsules Whole With A Full Glass Of Water On An Empty Stomach Or At Bedtime.
Do Not Take A 2nd Dose If Capsules Are Vomited. Monitor CBC Wkly During Concomitant Therapy And On Day 22 Of Each 28 Day Treatment Cycle, Followed By Wkly Blood Count Until Recovery.
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